GHK-Cu Peptide Vial

GHK-Cu Fact Sheet

Read A Guide for Researchers: How to use GHK-Cu

DISCLAIMER: By purchasing from Peptides by Megan you agree that you are purchasing Research Chemicals which are in no way intended for use in humans.

GHK-Cu, or copper peptide GHK-Cu, is a naturally occurring copper complex formed by the tripeptide glycyl-L-histidyl-L-lysine. First discovered in human plasma, this peptide has also been identified in saliva and urine. Known for their natural occurrence, copper peptides are protein fragments that have a strong affinity for copper ions, playing a crucial role in the body's regular functions. Extensive research has highlighted various roles and benefits of GHK-Cu in promoting health and wellness.

GHK-Cu and Wound Healing

It's fascinating to note that GHK-Cu has been observed to accelerate the healing of ischemic open wounds in rat studies, leading to quicker recovery times. This is achieved by stimulating the synthesis of collagen, elastin, and glycosaminoglycans - key components in the skin pivotal for effective wound healing. The same research highlighted a reduction in the concentration of metalloproteinases 2 and 9, enzymes responsible for breaking down the extracellular matrix during the wound healing process, in wounds treated with GHK-Cu [R]. 

Moreover, GHK-Cu is remarkable for its ability to boost the production of collagen and decorin, both vital for tissue regeneration and efficient wound healing. It enhances the 'stemness' and secretion of nourishing factors from mesenchymal stem cells. Additionally, GHK-Cu fosters skin remodeling, which plays a crucial role in wound healing and regeneration [R].

GHK-Cu Antioxidant and Anti-Inflammatory Effects

Studies have demonstrated that GHK-Cu (glycyl-l-histidyl-l-lysine copper) possesses impressive antioxidant and anti-inflammatory benefits. It can help combat oxidative stress in the skin by managing copper levels and affecting the activity of numerous antioxidant genes [R]. 

Interestingly, GHK-Cu has been found to alleviate acute lung injury in mice induced by lipopolysaccharides through its ability to suppress inflammation and mitigate oxidative damage [R].

GHK-Cu and Skin Remodeling and Regeneration

Research indicates that GHK-Cu significantly enhances the look of mature skin. Clinical studies highlight how both GHK and its copper-bound form exhibit powerful anti-inflammatory and tissue-restructuring capabilities [R]. 

At a concentration of 1nM, GHK-Cu boosts the production of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in human dermal fibroblasts, particularly when exposed to radiation. These factors are crucial in triggering blood vessel formation and improving circulation to damaged areas. The impressive qualities of GHK and its copper counterpart in skin remodeling, wound healing, regeneration, and its strong antioxidant and anti-inflammatory properties all support healthy aging [R].

GHK-Cu and Promotion of Blood Vessel Growth

GHK-Cu has shown potential in promoting the growth of blood vessels and nerves, while also enhancing the production of collagen, elastin, and glycosaminoglycans. This peptide, with its copper content, plays a pivotal role as it serves as an essential co-factor in angiogenesis—the process by which new blood vessels form. When GHK-Cu is combined with copper (II), it significantly boosts cell proliferation, differentiation, and production, particularly noted within a synthetic cryogel extracellular matrix (ECM) model. For more in-depth information, you can access these studies here and here.

GHK-Cu and Hair Growth

Discover how GHK-Cu can be your ally in achieving thicker, fuller hair. This powerful peptide encourages hair growth and increases thickness by enlarging your hair follicles and stimulating collagen production, a vital component for healthy hair [R]. 

But that's not all—GHK-Cu goes a step further by promoting the rejuvenation of human hair follicles. It does this by boosting the multiplication of dermal papilla cells (DPCs) while preventing their untimely death. Remarkably, GHK-Cu effectively counters the effects of dihydrotestosterone (DHT), a central player in hair loss, offering a powerful opportunity for hair restoration [R].

What Copper Peptide GHK-Cu Benefits Have Been Studied?

Several potential benefits and applications of the copper-binding peptide GHK-Cu have been studied.

Skin delivery and cosmetic applications: Liposomes have been investigated as carriers for GHK-Cu to deliver the peptide to the skin. GHK-Cu-loaded liposomes demonstrated inhibition of elastase activity, potentially reducing elastin degeneration and supporting skin structural integrity [R].

Skin remodeling and anti-aging: GHK-Cu has been shown to increase production of key skin proteins like collagen and modulate the skin remodeling process by stimulating both breakdown and synthesis of dermal matrix components, exhibiting anti-aging and tissue renewing properties [R].

Wound healing: Stimuli-responsive polymers based on polyaspartic acid, 2-acrylamido-2-methylpropane sulfonic acid, and sodium alginate were developed for controlled release of GHK-Cu. In vivo studies showed promising results for wound closure and healing [R].

Anti-inflammatory and protective effects in acute lung injury: GHK-Cu treatment reduced reactive oxygen species production, increased superoxide dismutase activity, and decreased pro-inflammatory cytokines in lipopolysaccharide-induced acute lung injury models, suggesting a potential therapeutic approach [R].

Antioxidant and antiglycant properties for neurodegenerative disorders: A new biotin-GHK conjugate (BioGHK) was synthesized and studied for its antioxidant, antiglycant, and antiaggregant properties, suggesting potential applications in treating or preventing biochemical reactions associated with neurodegenerative disorders [R].

Where can I find dosing information for my research? 

You'll find this information on our educational blog post about GHK-Cu for researchers here.

What other health benefits of GHK-Cu have researchers studied? 

Read more on the benefits of GHK-Cu for chronic illness here. 

At Peptides by Megan, our peptides are always 3rd party tested for quality and assurance, to guarantee the final product meets optimal standards for research use. For recent lab results, visit our FAQ page here. 

Read A Guide for Researchers: How to use GHK-Cu

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